Nothing is impossible with God. No matter how hopeless you feel, God can fill your life with hope. No matter how low you have sunk, he can lift you up high. We've seen examples in the lives of many, not all of them saints. I can testify to you that the highest points in my spiritual life followed some of the lowest points. "Never give up" can be foolish, unrealistic advice, but it works perfectly when you involve God, for he loves to help those in low spirits.